Publications
In Vitro Generation of Human Dendritic Cell Subsets from CD34+ Cord Blood Progenitors.
Bourdely P, Savoldelli R, Vetillard M, Anselmi G, Helft J, Guermonprez P.
Methods Mol Biol. 2023;2618:121-132.
In Vitro Generation of Murine Bone Marrow-Derived Dendritic Cells.
Gerber-Ferder Y, Bourdely P, Vetillard M, Guermonprez P, Helft
J.Methods Mol Biol. 2023;2618:83-92.
Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer.
Nalio Ramos R, Missolo-Koussou Y, Gerber-Ferder Y, Bromley CP, Bugatti M, Núñez NG, Tosello Boari J, Richer W, Menger L, Denizeau J, Sedlik C, Caudana P, Kotsias F, Niborski LL, Viel S, Bohec M, Lameiras S, Baulande S, Lesage L, Nicolas A, Meseure D, Vincent-Salomon A, Reyal F, Dutertre CA, Ginhoux F, Vimeux L, Donnadieu E, Buttard B, Galon J, Zelenay S, Vermi W, Guermonprez P, Piaggio E, Helft J.
Cell. 2022 Mar 31;185(7):1189-1207.e25.
Epithelial colonization by gut dendritic cells promotes their functional diversification.
Rivera CA, Randrian V, Richer W, Gerber-Ferder Y, Delgado MG, Chikina AS, Frede A, Sorini C, Maurin M, Kammoun-Chaari H, Parigi SM, Goudot C, Cabeza-Cabrerizo M, Baulande S, Lameiras S, Guermonprez P, Reis e Sousa C, Lecuit M, Moreau HD, Helft J, Vignjevic DM, Villablanca EJ, Lennon-Duménil AM.
Immunity. 2022 Jan 11;55(1):129-144.e8.
Dendritic Cells.
Tussiwand R., Guermonprez P., Yona S.
Book chapter In “William Paul’s Fundamental Immunology”
Edition 2021, M. Flajnik Editor. In press.
Harnessing Mesenchymal Stromal Cells for the Engineering of Human Hematopoietic Niches.
Pievani A, Savoldelli R, Poelchen J, Mattioli E, Anselmi G, Girardot A, Utikal J, Bourdely P, Serafini M, Guermonprez P.
Front Immunol. 2021 Mar 15;12:631279.
TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses.
Caronni N, Piperno GM, Simoncello F, Romano O, Vodret S, Yanagihashi Y, Dress R, Dutertre CA, Bugatti M, Bourdeley P, Del Prete A, Schioppa T, Mazza EMC, Collavin L, Zacchigna S, Ostuni R, Guermonprez P, Vermi W, Ginhoux F, Bicciato S, Nagata S, Benvenuti F.
Nat Commun. 2021 Apr 14;12(1):2237.
Monocyte Heterogeneity and Function.
Ginhoux F., Mildner A., Gautier E.L. , Schlitzer A., Jakubzick C., Varol C., Bain C., Guermonprez P.
Frontiers in Antigen Presenting Cells. 2021.
Development and function of human dendritic cells in humanized mice models.
Anselmi G, Helft J, Guermonprez P.
Mol Immunol. 2020 Sep;125:151-161.
Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells.
Bourdely P, Anselmi G, Vaivode K, Ramos RN, Missolo-Koussou Y, Hidalgo S, Tosselo J, Nuñez N, Richer W, Vincent-Salomon A, Saxena A, Wood K, Lladser A, Piaggio E, Helft J, Guermonprez P.
Immunity. 2020 Aug 18;53(2):335-352.e8.
Engineered niches support the development of human dendritic cells in humanized mice.
Anselmi G, Vaivode K, Dutertre CA, Bourdely P, Missolo-Koussou Y, Newell E, Hickman O, Wood K, Saxena A, Helft J, Ginhoux F, Guermonprez P.
Nat Commun. 2020 Apr 28;11(1):2054.
IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses.
Evnouchidou I, Chappert P, Benadda S, Zucchetti A, Weimershaus M, Bens M, Caillens V, Koumantou D, Lotersztajn S, van Endert P, Davoust J, Guermonprez P, Hivroz C, Gross DA, Saveanu L.
Nat Commun. 2020 Jun 2;11(1):2779.
Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses.
Purvis HA, Clarke F, Montgomery AB, Colas C, Bibby JA, Cornish GH, Dai X, Dudziak D, Rawlings DJ, Zamoyska R, Guermonprez P*, Cope AP*.
Front Immunol. 2020 Mar 4;11:376. * co-last authors.
Origin and development of classical dendritic cells.
Guermonprez P.*, Gerber-Ferder Y., Vaivode K., Bourdely P., Helft J.*. co-corresponding.
Int Rev Cell Mol Biol. 2019. 349:1-54.
Inflammasome activation: a monocyte lineage privilege (review).
Guermonprez P*, Helft J*. * co-corresponding authors.
Nat Immunol. 2019 Apr;20(4):383-385.
The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens.
Clarke F, Purvis HA, Sanchez-Blanco C, Gutiérrez-Martinez E, Cornish GH, Zamoyska R, Guermonprez P., Cope AP.
Sci Rep. 2018 Aug 23;8(1):12692.
Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.
Clarke F, Jordan CK, Gutiérrez-Martinez E, Bibby JA, Sanchez-Blanco C, Cornish GH, Dai X, Rawlings DJ, Zamoyska R, Guermonprez P, Cope AP, Purvis HA.
PLoS One. 2017 Oct 17;12(10).
Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection.
Péan CB, Schiebler M, Tan SW, Sharrock JA, Kierdorf K, Brown KP, Maserumule MC, Menezes S, Pilátová M, Bronda K, Guermonprez P, Stramer BM, Andres Floto R, Dionne MS.
Nat Commun. 2017 Mar 6;8:14642.
The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+Macrophages or Monocyte-Derived Dendritic Cells.
Menezes S, Melandri D, Anselmi G, Perchet T, Loschko J, Dubrot J, Patel R, Gautier EL, Hugues S, Longhi MP, Henry JY, Quezada SA, Lauvau G, Lennon-Duménil AM, Gutiérrez-Martínez E, Bessis A, Gomez-Perdiguero E, Jacome-Galarza CE, Garner H, Geissmann F, Golub R, Nussenzweig MC, Guermonprez P.
Immunity. 2016 Dec 20;45(6):1205-1218.
Inducible targeting of cDCs and their subsets in vivo.
Loschko J, Rieke GJ, Schreiber HA, Meredith MM, Yao KH, Guermonprez P, Nussenzweig MC.
J Immunol Methods. 2016 Jul;434:32-8.
Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets (review).
Gutiérrez-Martínez E, Planès R, Anselmi G, Reynolds M, Menezes S, Adiko AC, Saveanu L, Guermonprez P.
Front Immunol. 2015 Jul 17;6:363.
Intracellular Transport Routes for MHC I and Their Relevance for Antigen Cross-Presentation (review).
Adiko AC, Babdor J, Gutiérrez-Martínez E, Guermonprez P, Saveanu L.
Front Immunol. 2015 Jul 2;6:335.
An improved flow cytometry assay to monitor phagosome acidification.
Colas C, Menezes S, Gutiérrez-Martínez E, Péan CB, Dionne MS, Guermonprez P.
J Immunol Methods. 2014 Oct;412:1-13.
Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium.
Schreiber HA, Loschko J, Karssemeijer RA, Escolano A, Meredith MM, Mucida D, Guermonprez P* AND Nussenzweig MC.* . * equal contribution
J Exp Med. 2013 Sep 23;210(10):2025-39.
Differential effects of cocaine on histone posttranslational modifications in identified populations of striatal neurons.
Jordi E, Heiman M, Marion-Poll L, Guermonprez P, Cheng SK, Nairn AC, Greengard P, Girault JA.
Proc Natl Acad ScI. 2013 Jun 4;110(23):9511-6.
Inflammatory Flt3L is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection.
Guermonprez P*, Helft J, Claser C, Deroubaix S, Karanje H, Gazumyan A, Darasse-Jèze G, Telerman SB, Breton G, Schreiber HA, Frias-Staheli N, Billerbeck E, Dorner M, Rice CM, Ploss A, Klein F, Swiecki M, Colonna M, Kamphorst AO, Meredith M, Niec R, Takacs C, Mikhail F, Hari A, Bosque D, Eisenreich T, Merad M, Shi Y, Ginhoux F, Rénia L, Urban BC, Nussenzweig MC.
Nature Medicine. 2013 Jun;19(6):730-8. * corresponding author
Comment in : Nat Med. 2013 Jun;19(6):672-4. doi: 10.1038/nm.3227. Mast cells fuel the fire of malaria immunopathology. Engwerda CR, Kumar R.
Cross-presenting CD103+ dendritic cells are protected from influenza virus infection.
Helft J, Manicassamy B, Guermonprez P, Hashimoto D, Silvin A, Agudo J, Brown BD, Schmolke M, Miller JC, Leboeuf M, Murphy KM, García-Sastre A, Merad M.
J Clin Invest. 2012 Nov 1;122(11):4037-47.
Zinc finger transcription factor zDC is a negative regulator required to prevent activation of classical dendritic cells in the steady state.
Meredith MM, Liu K, Kamphorst AO, Idoyaga J, Yamane A, Guermonprez P, Rihn S, Yao KH, Silva IT, Oliveira TY, Skokos D, Casellas R, Nussenzweig MC.
J Exp Med. 2012 Aug 27;209(9):1583-93.
Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage.
Meredith MM, Liu K, Darrasse-Jeze G, Kamphorst AO, Schreiber HA, Guermonprez P, Idoyaga J, Cheong C, Yao KH, Niec RE, Nussenzweig MC.
J Exp Med. 2012 Jun 4;209(6):1153-65.
Route of antigen uptake differentially impacts presentation by dendritic cells and activated monocytes.
Kamphorst AO, Guermonprez P, Dudziak D, Nussenzweig MC.
J Immunol. 2010 Sep 15;185(6):3426-35.
Measuring pH, ROS production, maturation, and degradation in dendritic cell phagosomes using cytofluorometry-based assays (review).
Savina A, Vargas P, Guermonprez P, Lennon AM, Amigorena S.
Methods Mol Biol. 2010;595:383-402.
A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells.
Bougnères L, Helft J, Tiwari S, Vargas P, Chang BH, Chan L, Campisi L, Lauvau G, Hugues S, Kumar P, Kamphorst AO, Dumenil AM, Nussenzweig M, MacMicking JD, Amigorena S, Guermonprez P.
Immunity. 2009 Aug 21;31(2):232-44.
Comment in: Immunity. 2009 Aug 21;31(2):176-8. doi: 10.1016/j.immuni.2009.08.003. The good fat: a link between lipid bodies and antigen
cross-presentation. Desjardins M.
IRAP Identifies an Endosomal Compartment Required for MHC Class I Cross-Presentation.
Saveanu L, Carroll O, Weimershaus M, Guermonprez P, Firat E, Lindo V, Greer F, Davoust J, Kratzer R, Keller SR, Niedermann G, van Endert P.
Science. 2009 Jul 10;325(5937):213-7.
In vivo analysis of dendritic cell development and homeostasis.
Liu K, Victora GD, Schwickert TA, Guermonprez P, Meredith MM, Yao K, Chu FF, Randolph GJ, Rudensky AY, Nussenzweig M.
Science. 2009 Apr 17;324(5925):392-7.
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.
Waskow C, Liu K, Darrasse-Jèze G, Guermonprez P, Ginhoux F, Merad M, Shengelia T, Yao K, Nussenzweig M.
Nat Immunol. 2008 Jun;9(6):676-83.
Selection of an antibody library identifies a pathway to induce immunity by targeting CD36 on steady-state CD8 alpha+ dendritic cells.
Tagliani E, Guermonprez P, Sepúlveda J, López-Bravo M, Ardavín C, Amigorena S, Benvenuti F, Burrone OR.
J Immunol. 2008 Mar 1;180(5):3201-9.
Neonatal and adult microglia cross-present exogenous antigens.
Beauvillain C, Donnou S, Jarry U, Scotet M, Gascan H, Delneste Y, Guermonprez P, Jeannin P, Couez D.
Glia. 2008 Jan 1;56(1):69-77.
Neutrophils efficiently cross-prime naive T cells in vivo.
Beauvillain C, Delneste Y, Scotet M, Peres A, Gascan H, Guermonprez P, Barnaba V, Jeannin P.
Blood. 2007 Oct 15;110(8):2965-73. Epub 2007 Jun 11.
Cellular pathways for the cross presentation or bacterial antigens (review).
Bougnère-Vermont L, Guermonprez P
In “Interactions between dendritic cells and bacteria”, Editor M. Rescigno, Cambridge University Press, 2007.
Critical role for the NADPH oxidase NOX2 in the control of phagosomal pH and of antigen cross presentation in dendritic cells
Savina A, Jancic C, Hugues S, Guermonprez P, Vargas P, Cruz Moura I., Lennon-Duménil AM, Seabra MC, Raposo G and Amigorena S
Cell. 2006 Jul 14;126(1):205-18.
Antigen presentation by B lymphocytes: how receptor signaling directs membrane trafficking (review).
Vascotto F, Le Roux D, Lankar D, Faure-Andre G, Vargas P, Guermonprez P, Lennon-Dumenil AM.
Curr Opin Immunol. 2006 Nov 29
Pathways for antigen cross presentation (review).
Guermonprez P, Amigorena S.
Springer Semin Immunopathol. 2005 Jan;26(3):257-71.
An export-reimport model for cross presentation of particulate antigens by MHC class I molecules in dendritic cells (review).
Guermonprez P, Amigorena S.
J Soc Biol. 2004;198(2):121-2.
Benznidazole, a drug used in Chagas' disease, ameliorates LPS-induced inflammatory response in mice.
Pascutti MF, Pitashny M, Nocito AL, Guermonprez P, Amigorena S, Wietzerbin J, Serra E, Bottasso O, Revelli S.
Life Sci. 2004 Dec 24;76(6):685-97.
Control of cross-presentation during dendritic cell maturation.
Gil-Torregrosa BC, Lennon-Dumenil AM, Kessler B, Guermonprez P, Ploegh HL, Fruci D, van Endert P, Amigorena S.
Eur J Immunol. 2004 Feb;34(2):398-407.
ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells.
Guermonprez P, Saveanu L, Kleijmeer M, Davoust J, Van Endert P, Amigorena S.
Nature. 2003 Sep 25;425(6956):397-402.
Comment in: Nature. 2003 Sep 25;425(6956):351-2. Immunology: professional secrets. Roy CR.
In vivo receptor-mediated delivery of a recombinant invasive bacterial toxoid to CD11c + CD8 alpha -CD11bhigh dendritic cells.
Guermonprez P, Fayolle C, Rojas MJ, Rescigno M, Ladant D, Leclerc C.
Eur J Immunol. 2002 Nov;32(11):3071
Dendritic cells are host cells for mycobacteria in vivo that trigger innate and acquired immunity.
Jiao X, Lo-Man R, Guermonprez P, Fiette L, Deriaud E, Burgaud S, Gicquel B, Winter N, Leclerc C.
J Immunol. 2002 Feb 1;168(3):1294-301.
Antigen presentation and T cell stimulation by dendritic cells (review).
Guermonprez P, Valladeau J, Zitvogel L, Thery C, Amigorena S.
Annu Rev Immunol. 2002;20:621.
The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18).
Guermonprez P, Khelef N, Blouin E, Rieu P, Ricciardi-Castagnoli P, Guiso N, Ladant D, Leclerc C.
J Exp Med. 2001 May 7;193(9):1035-44.
Antigen delivery using bacterial toxins (review).
Guermonprez P, Ladant D, Fayolle C, Ullmann A, Leclerc C.
Medecine Sciences. 2000;16(5):653-662.
Bordetella pertussis adenylate cyclase toxin: a vehicle to deliver CD8-positive T-cell epitopes into antigen-presenting cells (review).
Guermonprez P, Fayolle C, Karimova G, Ullmann A, Leclerc C, Ladant D.
Methods Enzymol. 2000;326:527-42
Immune responses induced by recombinant BCG strains according to level of production of a foreign antigen: malE.
Himmelrich H, Lo-Man R, Winter N, Guermonprez P, Sedlik C, Rojas M, Monnaie D, Gheorghiu M, Lagranderie M, Hofnung M, Gicquel B, Clement JM, Leclerc C.
Vaccine. 2000 Jun 1;18(24):2636-47
Delivery of CD8(+) T-cell epitopes into major histocompatibility complex class I antigen presentation pathway by Bordetella pertussis adenylate cyclase: delineation of cell invasive structures and permissive insertion sites.
Osicka R, Osickova A, Basar T, Guermonprez P, Rojas M, Leclerc C, Sebo P.
Infect Immun. 2000 Jan;68(1):247-56.
mAb against hen egg-white lysozyme regulate its presentation to CD4(+) T cells.
Guermonprez P, Lo-Man R, Sedlik C, Rojas MJ, Poljak RJ, Leclerc C.
Int Immunol. 1999 Nov;11(11):1863-72.
Direct delivery of the Bordetella pertussis adenylate cyclase toxin to the MHC class I antigen presentation pathway.
Guermonprez P, Ladant D, Karimova G, Ullmann A, Leclerc C.
J Immunol. 1999 Feb 15;162(4):1910-6.
The rate of dissociation between antibody and antigen determines the efficiency of antibody-mediated antigen presentation to T cells.
Guermonprez P, England P, Bedouelle H, Leclerc C.
J Immunol. 1998 Nov 1;161(9):4542-8.